NAD+ is a critical component of a healthy aging program.
Every cell requires it for hundreds of processes. These include activity of sirtuins, cellular guardians linked to prolonged lifespan and healthspan.
NAD+ levels and sirtuin expression diminish with advancing age, accelerating aging processes and degenerative disease risk.
Nicotinamide riboside is a compound that increases cellular NAD+ levels, enhancing sirtuin activity. New research has found that maintaining more youthful NAD+ levels can slow certain aspects of biological aging.
NAD+ also improves the health of stem cells that can replace dead and dying cells and keep vital tissues functioning.
This not only extends lifespan, but also helps reduce the risk for metabolic disease, obesity, cardiovascular disease, cognitive dysfunction, and more.
NAD+ for Healthy Longevity
- NAD+ (nicotinamide adenine dinucleotide) is an essential cofactor for hundreds of cellular processes
- Sirtuins, cellular defenders linked to longer life and protection from disease, require optimal NAD+ levels to function.
- Levels of NAD+ drop with age, accelerating aging. Nicotinamide riboside helps replenish NAD+ levels.
- Boosting NAD+ has been tied to improved mitochondrial function, healthier stem cells that rejuvenate tissues, and increased longevity.
- Maximizing NAD+ also protects tissues from the effects of age and may reduce risk for age-related diseases such as cognitive decline, cardiovascular disease, and metabolic disease.
NAD+ is a cellular coenzyme that’s found in every cell of our bodies. NAD+ is necessary to create adenosine triphosphate (ATP), the compound the body uses for fuel. NAD+ helps maintain youthful levels of NAD+ with nicotinamide riboside, to help fight general fatigue at the cellular level.
By encouraging production of nicotinamide adenine dinucleotide (or NAD+), helps protect against cellular aging.
Defense Against Cellular Aging
If you are experiencing fatigue and lack of motivation, it may be due to the age-related decline in NAD+ levels and subsequent impairment of healthy cellular metabolism. NAD+ (nicotinamide adenine dinucleotide) promotes systemic youthful functions and is found in every cell in the body. In addition, NAD+ plays an essential role in regulating genes that control aging.
How To Boost NAD+ Levels Within Your Cells
Nicotinamide riboside increases cellular levels of NAD+ in the body. For the first time, aging humans have an effective and affordable method to boost the critical NAD+ enzyme for refreshed vitality. Nicotinamide riboside represents an innovative advance to combat aging that functions via unique mechanisms.
Multiple Benefits Of Increasing NAD+ Cellular Levels
Nicotinamide riboside has been documented to help replenish cellular NAD+ and in the process:
Promote sirtuin (SIRT1 and SIRT3) gene activation,
Enhance growth and efficiency of mitochondria—supporting energy levels and physical performance,
Favorably modulate metabolism,
Contribute to neuronal health—supporting cognitive function during aging,
Promote insulin sensitivity—supporting healthy blood sugar levels in those within the normal range.
Increasing NAD+ is a promising way to self-renew existing stem cells in order to extend lifespan and prevent disease.
A study published in June 2019 shows how a NAD+ boosting supplement called nicotinamide riboside increased stem cell colonies by 75% in the gut of aging mice.
Other studies point to the role of NAD+ in restoring circadian rhythms needed for restorative sleep.
Age-related sleep deterioration and digestive disorders adversely impact quality of life and accelerate degenerative processes in older individuals.
The most critical role of NAD+ is DNA repair. Each day, our DNA sustains numerous breaks that are repaired by NAD+-dependent enzymes.
With age, NAD+ levels plummet. Another study published in 2019 showed that a modest dose of nicotinamide riboside boosted NAD+ levels by 51% in overweight humans.
New data reveal how NAD+ improves functionality of existing stem cells and replenishes mitochondria in cells throughout the body.
Nicotinamide Riboside Boosts NAD+
Higher levels of NAD+ correlate with improved health and a lower occurrence of age-related disorders.
Lower NAD+ levels contribute to many diseases of older age, including sleep disturbances, metabolic disorders, diabetes, cardiovascular disease, and cognitive decline.
An easy way to boost NAD+ levels is with nicotinamide riboside, which converts to NAD+ in your body.
Pharmaceutical grade transdermal cream allows Nicotinamide riboside to enter the blood stream at very high levels 80%+ those of IV infusion. Just like with IV infusions NR is not effected by the stomach.
Transdermal application of Nicotinamide riboside is a safer and much more convenient option when compared to IV infusions taking many hours.
Save Money on stem cell infusions some with unknown safety and efficacy.
Current pricing in the USA for NAD+ iv infussions
Low Dose 250mg 1-2 hrs $ 299
Regular Dose 500mg 2-4 hrs $ 599
High Dose 1000mg 2-6 hrs $1199
Our Transdermal cream is formulated using a pharmaceutical grade transdermal cream the same cream that is used in hormone replacement gels, it is not a skin care cream but designed to carry NR into the blood stream for systemic circulation.
The NAD+ cream is available in a 20ml jar containing 4000mg of nicotinamide riboside in a transdermal cream.
Cost is US$130
How to apply:
Wash and dry the area you wish to apply the cream to, most people use the inner forearm area and inside of wrist.
Apply desired amount of transdermal cream to clean area and rub into skin with a clean dry hand, keep on rubbing in a circular motion until cream is completely absorbed into skin.
Once Levels of NAD+ are restored it is recommended to use an oral nicotinamide riboside containing product daily to keep levels high.
Day 1 Start off with 1ml (200mg of NR) once to see reactions to cream.
Day 2 Apply 2.5ml (500mg of NR) once.
Day 3 Apply 2.5ml to 5ml cream once.
Repeat day 3 application for the desired length of days total usually range between 4 to 10 days.
POPULAR ANTIAGING PROTOCOL
Anti-aging treatment in the form of three applications, with one being administered every other week. After the first three NAD treatments, a maintenance is performed monthly. Anti-aging treatments with NAD are administered with 500mg of NAD per dose.
- week 1 2.5ml cream (apply once)
- week 3 2.5ml cream (apply once)
- week 5 2.5ml cream (apply once)
- week 9 2.5ml cream (apply once)
- week 13 2.5ml cream (apply once)
- and so on.
Replacing Old Mitochondria and Improving Mitochondrial Function
Mitochondria are the power suppliers of every cell, breaking down nutrients like sugars and fats into energy the cell can use to do work. When mitochondria age, they become dysfunctional, contributing to many illnesses.
Evidence indicates that sirtuins perform cellular housekeeping that includes replacing old and damaged mitochondria with healthy, new ones. This process rejuvenates cells and improves their metabolism while maintaining their optimal function.
Because sirtuin activity is dependent on NAD+ (which plummets with age), supplementation with nicotinamide riboside can help preserve cellular functions.
Replenishing NAD+ levels with nicotinamide riboside resulted in enhanced mitochondrial function that:
Rejuvenated aging bone marrow cells, helping to maintain immune function and prevent bone marrow failure and related diseases,
Improved muscle function and reduced muscle pathology in an animal model of muscular dystrophy, and
Lessened liver inflammation and induced mitochondrial biogenesis, the formation of new mitochondria, in mice liver cells.
Rejuvenating Stem Cells
Healthy stem cells in tissues are needed to replace dead or dying functional cells with new ones. But stem cells age and become dysfunctional over time, causing tissues to deteriorate and increasing risk for disease.
Nicotinamide riboside intake can help prevent this. In a study on elderly mice, nicotinamide riboside replenished NAD+ levels, which improved mitochondria function that rejuvenated stem cells in muscles. It also prevented the deterioration of muscle, skin, and brain stem cells.
This prolonged the lifespan of old mice by approximately 5%. Though this number may not seem huge, the supplementation only began when the mice were already two years old, the equivalent of about 80 years in humans.
A more significant effect may occur if NAD+ is boosted earlier in life, and combined with interventions like resveratrol that prompts cells to express sirtuin proteins that NAD+ then activates.
New studies corroborate a beneficial impact of NAD+ on other stem cells. In one study, researchers looked at adult mice gut stem cells, which typically dwindle in older age. Injuries to the gut of these older animals have a difficult time healing.
Nicotinamide riboside increased these digestive tract stem cell colonies by approximately 75%, improving the ability to recover from injury. This finding has favorable implications for older individuals suffering from digestive tract discomforts.