Longevity & healthspan · evidence-first
What actually works for longevity — and where to get it, without the hype.
We read the primary literature so you don't have to. Every claim is cited, every product comparison states the trade-offs, and we never sell prescription drugs. Start with the flagship compound or compare the supplements people actually ask about.
Start here
Each hub is a plain-language, cited guide to one compound or test — with an honest buying view where it applies.
Rapamycin The flagship. What the evidence shows, side effects, dosing debate, cost and access. 
Best NMN supplements NAD⁺ precursors compared by evidence, purity and dose — not by hype. 
Best NAD boosters What actually raises NAD⁺: NR vs NMN vs the rest. 
Resveratrol The bioavailability problem most brands skip. 
Urolithin A & Mitopure Mitophagy, and the 'you may already make it' nuance. 
Spermidine Autophagy, food sources, and the observational-vs-causal gap. 
Senolytics Fisetin and quercetin — clearing senescent cells, honestly assessed. 
Metformin for longevity The TAME trial, the exercise trade-off, and access. 
Biological age tests What epigenetic clocks measure — and their reliability limits. Why trust this site
Per-claim citations
Every health claim links to primary literature (PubMed / DOI) or a reputable secondary source. No claim floats free.
Honest comparisons
Product roundups tell you who each option is not for, and rank by strength of human evidence — not by commission.
No prescription sales
Rapamycin, metformin and GLP-1 drugs are prescription-only. We explain them and point to legitimate routes — never a grey-market checkout.
We show our uncertainty
Where the human evidence is early or missing, we say so plainly. "Promising in mice" is not "proven in people."
Own a longevity or health brand?
Rapamycin.store publishes sponsored and guest posts on an aged, topically-relevant domain, and offers display advertising. Tell us what you want to promote and we'll send our current options.