Many of our customers have asked for a non transdermal skin cream that will only work on the area that the cream is applied to and not be systemic such as a transdermal cream many work.
Rapamycin has an anti-aging effect on the skin, because rapamycin has an anti-aging effect on every organ of the human body, it is easy to see the effects of Rapamycin on the skin. Here we are interested in more youthful looking skin.
Many of our customers who are currently using our capsules have asked for a Rapamycin containing skin cream to help to turn back the clock a few years and look younger.
Rapamycin has an anti-aging effect on the brain, heart, muscle, joints, bone, kidney, immune system, and eyes demonstrated in human or animal studies. The mechanism shown is a study is the basic anti-aging mechanism. mTOR and senescent cells are driving aging and rapamycin slows down this process and slows aging.
- Topical rapamycin treatment reduced expression of senescence regulator p16INK4A.
- Rapamycin improves cytokeratin 5/6 distribution with more tightly associated with basal layer.
- Topical rapamycin increases collagen VII in the basement membrane.
- Clinical improvement: Of the 13 subjects, (completing study) all except 2 showed improvement in clinical signs of cutaneous aging. The most notable improvement was a decrease in the prominence of veins and tendons, a hallmark of age-related volume loss of the hands. Fine wrinkling was also improved, consistent with the increase in collagen VII. The dyspigmentation and dull appearance associated with photoaging was also consistently improved. These changes were evident approximately 4 months following the initiation of treatment, and continued improvement was noted upon subsequent visits.
Rapamycin treatment improves clinical signs of aging in the skin. Clinical improvement in a 65-year-old woman (a) and a 67-year-old woman (b) following application of 10 μM rapamycin cream for 6–8 months. The placebo-treated hand is provided for comparison. in c, overall clinical improvement on 3 scales, the Glogau Classification of Photoaging, wrinkling measured on a 1-4 Likert scale, and the Merz Hand Grading Scale for aging skin, is presented for all subjects completing the study. Lower score on all scales correlates with reduced clinical severity
How to Apply
Apply the topical rapamycin cream (0.010%) to the skin once every 24 to 48 hours in the evening .
Supplied as: 100 gram paraffin soft white bp cream with 0.010% rapamycin.
This cream will not introduce Rapamycin into your body and will only effect the skin it is applied directly to. The .001 % preparation in a study had no systemic absorption and no side effects were reported.