Rapamycin.store Longevity & healthspan · evidence-first

Editorial policy

Editorial standards

The rules we hold ourselves to on a topic where being wrong has real consequences.

By The Rapamycin.store Research Desk Last updated Policy document
Health claims cite primary literature. Compound pages carry an evidence grade. Paid relationships never set a grade.

Evidence and sourcing

Every health claim is supported by a citation to primary literature (peer-reviewed studies via PubMed or DOI) or to a reputable secondary source such as a government health body. The rapamycin page is a worked example, and the evidence table shows every grade side by side.

We tell you which tier a claim rests on, in this order of weight:

  1. human randomized controlled trials;
  2. observational human studies;
  3. animal or cell studies, always labeled as such.

How we grade evidence

Compound and product pages carry an evidence badge:

  • Strong human evidence: supported by multiple human randomized trials with consistent results.
  • Early / mixed evidence: some human data, or strong animal data with limited or conflicting human results.
  • Limited evidence: mainly anecdotal, mechanistic, or preclinical; human outcome data is thin or absent.

No medical advice, no prescription sales

Nothing on this site is medical advice or a substitute for a qualified professional who knows your history. We do not diagnose, prescribe, or recommend a personal dose. Our medical disclaimer sets out the limits in full.

For prescription drugs (rapamycin, metformin, GLP-1 receptor agonists) we provide information only and point to legitimate routes: a licensed clinician or regulated telehealth. We never sell them or link to grey-market sources.

Independence and disclosure

We earn affiliate commissions and publish sponsored and guest content. Those relationships never determine our assessments or our evidence grades, and they are always disclosed: affiliate links carry an affiliate disclosure, and paid placements are labelled. We also disclose conflicts of interest in the research we cite: for example, when a trial was funded by the company selling the product.

Authorship and expertise

Content is published under The Rapamycin.store Research Desk. Who runs the desk is on the about page, and the researchers we quote, with their disclosed ties, are listed under our quoted experts.

  • An independent editorial desk, not a clinician. No medical credentials are claimed. Every health claim is checked against primary literature and cited.

We do not claim clinical credentials we don't have, and we are working to add a named, credentialed medical reviewer.

Corrections policy

When new evidence changes the picture, we update the page and note the change. Accuracy is the entire point of this site.

If you find an error, email [email protected]. Substantive corrections are made promptly and, where material, flagged on the page.

Language we avoid

We don't use the vocabulary of marketing: words that promise a result, a hidden answer, or a certainty the evidence cannot give. They signal selling, not evidence, and they have no place on a page about your health.

Every claim passes the same funnel - primary source, appraisal, grade - before it reaches a page.

References

6 sources, all link-checked; oldest check

  1. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Guyatt GH et al. BMJ 2008;336:924.The framework behind the strong / mixed / limited evidence grades used across this site.Verified Sep 15, 2026
  2. Cochrane Handbook for Systematic Reviews of Interventions. Higgins JPT et al., version 6.5, 2024.Risk-of-bias methodology used when this desk appraises a trial.Verified Sep 15, 2026
  3. Why most published research findings are false. Ioannidis JPA. PLoS Medicine 2005;2(8):e124.The base-rate argument for treating any single positive study as provisional.Verified Sep 15, 2026
  4. Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals. International Committee of Medical Journal Editors, updated 2025.The conflict-of-interest and authorship conventions this desk follows for a lay publication.Verified Sep 15, 2026
  5. PubMed. US National Library of Medicine, National Institutes of Health.The index every citation on this site is checked against before publication.Verified Sep 15, 2026
  6. Health Products Compliance Guidance. US Federal Trade Commission, December 2022.The substantiation standard for health claims in advertising: competent and reliable scientific evidence.Verified Sep 15, 2026

Every link above is re-requested on a schedule by an automated checker; the date shown is when it last answered. Publishers that block automated requests are marked as such rather than reported broken. Our editorial standards explain how a source gets cited here in the first place.

Filed by the Rapamycin.store evidence desk. Each source is re-checked when the page is reviewed.