The Research Desk
Longevity science, in plain language
Every article below is checked against primary literature — trials, reviews, and preprints — and updated when the evidence moves. No hype, no miracle words.
Rapamycin · safety Rapamycin side effects by dose and schedule
Rapamycin side effects depend heavily on dose. High continuous doses carry real risks; low intermittent longevity dosing aims to reduce them
Updated July 2026
Longevity science Autophagy and fasting: how cellular cleanup works
Autophagy is the cell's cleanup system. Here is how fasting and mTOR inhibition trigger it, in plain language — and an honest look at the evidence.
Updated July 2026
Longevity science Blue zones: what the longest-lived people do
What the blue zones are, the shared lifestyle habits behind them, and an honest look at why the evidence is observational rather than proof
Updated July 2026
Longevity in practice Bryan Johnson Blueprint protocol explained
A neutral explainer of Bryan Johnson's Blueprint protocol — the diet, sleep, exercise, and supplement stack
Updated July 2026
Best-evidenced basics Creatine for healthy aging: beyond the gym
Creatine is one of the best-evidenced supplements for healthy aging — muscle and sarcopenia protection, plus a preliminary cognitive angle.
Updated July 2026
Senolytics · fisetin Fisetin benefits and senolytic evidence
Fisetin is a flavonoid with a strong senolytic reputation from mouse studies. What the benefits really are, what human evidence exists
Updated July 2026
Longevity science The hallmarks of aging explained simply
The hallmarks of aging in plain language — the original nine from 2013 and the 2023 update to twelve, and how each connects to real longevity interventions.
Updated July 2026
Rapamycin · mechanism How rapamycin works and the mTOR pathway
A plain-language explainer of how rapamycin works: it inhibits mTORC1, the cell's master growth switch
Updated July 2026
Building a regimen Longevity supplement stacks compared honestly
Common longevity supplement stacks compared with honest, evidence-tiered framing — the foundational basics, the NAD-and-resveratrol pairing
Updated July 2026
NAD+ · safety NAD supplement side effects and safety
An honest safety review of NAD supplements: NR and NMN are generally well tolerated in short trials, the niacin flushing myth explained
Updated July 2026
Rapamycin · alternatives Natural alternatives to rapamycin: what has evidence
No food or supplement reproduces rapamycin's mTOR inhibition. An honest look at the natural options sometimes discussed — spermidine, periodic fasting
Updated July 2026
NMN · benefits NMN benefits: what the research supports
A cited, hype-free look at NMN benefits — the NAD+ precursor mechanism, the human trial on insulin sensitivity, and what is not yet shown in people.
Updated July 2026
NMN · safety NMN side effects and safety review
An honest NMN safety review: generally well tolerated in short trials at studied doses, but long-term data is limited.
Updated July 2026
NAD+ · precursors compared NMN vs NAD vs NR: which one actually works
NMN vs NAD vs NR explained without hype: NAD+ is the target molecule, NMN and NR are precursors, and NR has the most human data behind it.
Updated July 2026
Rapamycin · dogs Rapamycin and the Dog Aging Project explained
What the Dog Aging Project and its TRIAD trial are testing: whether low-dose rapamycin improves healthspan and heart function in companion dogs.
Updated July 2026
Rapamycin · dosing Rapamycin dosage for longevity: what protocols people use
There is no established optimal rapamycin dose for longevity. This is a plain, honest look at the intermittent off-label patterns people discuss
Updated July 2026
Rapamycin · comparison Rapamycin vs metformin for longevity compared
Rapamycin vs metformin for longevity: different mechanisms, different evidence. Rapamycin has stronger mouse data; metformin has human epidemiology.
Updated July 2026
Resveratrol · stacking Resveratrol and NAD: do they work better together?
Does stacking resveratrol with NAD boosters help? The sirtuin-NAD+ mechanism explained, and why the human evidence for the combination is weak.
Updated July 2026
Resveratrol · the evidence Resveratrol benefits: what the evidence shows
Resveratrol benefits examined honestly: the sirtuin hypothesis, the poor-bioavailability problem, and what the modest human evidence actually supports.
Updated July 2026
Longevity science Cellular senescence and senolytics explained
A plain-language guide to senescent 'zombie' cells, the SASP, why they build up with age as a hallmark of aging, and what senolytics actually aim to do.
Updated July 2026
Spermidine · the evidence Spermidine benefits and the foods highest in it
Spermidine benefits and the richest food sources: the autophagy mechanism, the mortality association from cohort data
Updated July 2026
Urolithin A · the evidence Urolithin A benefits and mitochondrial health
Urolithin A benefits explained: the mitophagy mechanism, muscle-endurance trials in older adults, and the conflict-of-interest caveat.
Updated July 2026
Longevity science What is biological age and how to measure it
What biological age means, how it differs from your birthday age, and how epigenetic clocks measure it — plus the honest reliability caveats.
Updated July 2026
NAD+ · the basics What is NAD and why it declines with age
A plain-language guide to NAD+: what it does in energy metabolism and repair, why it declines with age, and how precursors like NR and NMN aim to raise it.
Updated July 2026
Rapamycin basics What is rapamycin? A plain-language guide
What rapamycin is, in plain English: a bacterial compound discovered on Easter Island, approved as the drug sirolimus
Updated July 2026