Researcher profile
Matt Kaeberlein, PhD
He co-authored the 2005 work identifying the fluorophore artifact that undermined the original sirtuin–resveratrol result, and he co-directs the only randomized lifespan trial running in a large mammal outside a laboratory colony.
- Role
- Biogerontologist; co-founder of the Dog Aging Project; CEO of Optispan
- Affiliation
- formerly Professor of Pathology, University of Washington
- Topics
- Rapamycin · Dogs & TRIAD · Resveratrol · Supplement scepticism
- Their work
- Search PubMed dogagingproject.org
Why we quote Kaeberlein
He co-authored the 2005 work identifying the fluorophore artifact that undermined the original sirtuin–resveratrol result, and he co-directs the only randomized lifespan trial running in a large mammal outside a laboratory colony.
Matt Kaeberlein, PhD is one of the researchers quoted here; the others quoted alongside Matt are listed with the same disclosures.
Where they stand, and who pays
Runs a commercial healthspan company, and is the most consistently sceptical voice quoted on this site about the supplement industry, including categories he could profit from.
Stating this next to the quote rather than at the bottom of a disclosures page is the whole point. A concession made against a commercial interest is stronger evidence than a neutral summary; a claim made in line with one is weaker. You cannot weigh either without knowing which you are reading.
Everything we quote them saying
All 9 lines, verbatim, in the order they appear in the site's citation index. Each one links to the recording and to the page it is used on.
A study that would take 30 years in people will take three and a half years in dogs.
Used on Rapamycin for dogs: what the 24-dog trial actually showed
About 15% of people taking rapamycin 6 mg once a week will develop mouth sores.
Used on Rapamycin Side Effects: What the Dose Actually Changes , Rapamycin: What the Evidence Shows
Dogs age very much like we do, they just do it seven to 10 times faster.
Used on Rapamycin and the Dog Aging Project: What TRIAD Is Testing
Nobody's going to make enough money off of rapamycin to do the clinical trials that really should be done.
Used on Rapamycin vs Metformin: What the New Meta-Analysis Changed
One dog got high triglycerides. That's it.
Used on Rapamycin for dogs: what the 24-dog trial actually showed
Only 12 weeks of rapamycin was enough to increase remaining life expectancy by more than 60%.
Used on How Rapamycin Works on mTOR, in Plain Language , Rapamycin Dosage for Longevity: What the Numbers Rest On
Take the fluorophore off, and resveratrol does absolutely nothing to this chemical reaction.
Used on Resveratrol Supplement: What Happened to the Longevity Claim
The net effect of resveratrol is a 0% effect on lifespan.
Used on Resveratrol Benefits, Sorted by What Was Measured in Humans , Resveratrol Supplement: What Happened to the Longevity Claim
There's nothing saying that 6 mg is the best dose.
Used on Rapamycin Dosage for Longevity: What the Numbers Rest On
Pages this research informs
Each page below cites this researcher directly, so you can see the claim a quote supports in its full context.
- How Rapamycin Works on mTOR, in Plain Language
- Rapamycin and the Dog Aging Project: What TRIAD Is Testing
- Rapamycin Dosage for Longevity: What the Numbers Rest On
- Rapamycin Side Effects: What the Dose Actually Changes
- Rapamycin vs Metformin: What the New Meta-Analysis Changed
- Resveratrol Benefits, Sorted by What Was Measured in Humans
- Rapamycin for dogs: what the 24-dog trial actually showed
- Rapamycin: What the Evidence Shows
- Resveratrol Supplement: What Happened to the Longevity Claim
The standing disclaimer
Matt Kaeberlein, PhD has no relationship with Rapamycin.store and does not endorse anything on it.
- They have not reviewed this site or any page that quotes them.
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Researchers who want to set out a position in their own words, rather than be quoted, can write for the desk directly.
References
3 sources, all link-checked; oldest check
- Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals. International Committee of Medical Journal Editors, updated 2025.The conflict-of-interest and authorship conventions this desk follows for a lay publication.Verified Sep 14, 2026
- PubMed. US National Library of Medicine, National Institutes of Health.The index every citation on this site is checked against before publication.Verified Sep 14, 2026
- GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Guyatt GH et al. BMJ 2008;336:924.The framework behind the strong / mixed / limited evidence grades used across this site.Verified Sep 14, 2026
Every link above is re-requested on a schedule by an automated checker; the date shown is when it last answered. Publishers that block automated requests are marked as such rather than reported broken. Our editorial standards explain how a source gets cited here in the first place.
Filed by the Rapamycin.store evidence desk. Each source is re-checked when the page is reviewed.
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